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| DAE (chemotherapy) ： ウィキペディア英語版 |
ADE (chemotherapy)
ADE is a chemotherapy regimen most often used as an induction or consolidation regimen in acute myelogenous leukemia, especially in poor-risk patients or those refractory to the standard first-line induction with standard "7+3" regimen or who are relapsed after the standard chemotherapy.
ADE regimen consists of three drugs:
# Ara-C (cytarabine) - an antimetabolite;
# Daunorubicin - an anthracycline antibiotic that is able to intercalate DNA and thus disrupt the cell division cycle, preventing mitosis;
# Etoposide - a topoisomerase inhibitor.〔(Fludarabine and cytosine are less effective than standard ADE chemotherapy in high-risk acute myeloid leukemia, and addition of G-CSF and ATRA are not beneficial: results of the MRC AML-HR randomized trial )〕
== Dosing regimen ==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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